India - India's growing conflict between trade and transport : issues and options

India was a rather marginal participant in world trade during the early years after independence. Since 1980, however, the structure and orientation of Indian export trades have undergone fundamental changes. Substantial progress has been made in diversifying the export base - manufactured goods have increased and the traditional bulk sector has shrunk. Key targets for the export of manufactured goods are the European, Japanese and North American markets. However, these markets are characterized by increasingly efficient trade logistics, including containerization and multimodal transport arrangements. To enable further trade growth, India is confronted with a need to tie into the highly organized international trade logistics networks, something the country is totally unprepared to cope with in terms of demanding logistical arrangements. There is a real danger that India's trade performance will deteriorate, if no corrective measures are taken. A highly fragmented service industry, outdated regulations, heavy Government control, a constrained private sector, and largely inadequate infrastructure have curtailed efforts to improve trade logistics, including containerization and multimodal transport arrangements in India. Major reforms are called for so that an effective framework for initiating urgently required system adjustments can be established.Environmental Economics&Policies,Economic Theory&Research,TF054105-DONOR FUNDED OPERATION ADMINISTRATION FEE INCOME AND EXPENSE ACCOUNT,Transport and Trade Logistics,Common Carriers Industry

The international ocean transport industry in crisis : assessing the reasons and outlook

Until 1980, the world merchant fleet expanded rapidly in response to thriving seatrade markets. Since then, it has not grown much. The industry did not adjust effectively to periodic global recession, and the fleet's earnings deteriorated as the gap widened between the supply of tonnage and the demand for transport. The unpredictability of seatrade markets and the changing structure of demand for ocean transport complicated shipowners'efforts to retrench and draw up defensive strategies. Advances in ship design and ocean transport technologies allowed shipowners to adjust to the greater need for specialized vessels, but chose to retain their assets and their adoption was expensive. Most shipowners added a few new vessels after 1980, often supported by government subsidies. Government regulations created serious distortions in ocean transport and impeded free market adjustments. The most serious issues the industry faces are a critically overaged fleet and shortage of capital. Becauseof reduced freight earnings, maintenance has been neglected, leading to frequent structural failure. Ship casualties - often with serious envionmental damage - have reached alarming levels. The deteriorating safety record has caused insurance costs to escalate and has provoked calls for stricter liability rules, stringent technical standards, and rigorous inspection. Enforcement would make ocean transport more expensive. To meet expected demand for ocean transport safely and efficiently, a great deal of overaged tonnage must be replaced, maintenance must be improved, and new tonnage has to be added. The estimated cost: almost US$400 billion in constant 1992 prices. But traditional financing, through mortgage lending and government subsidy, is becoming scarce. Leasing or cashflow-based lending are promising alternatives, but they required predictable revenue streams based on long-term freight contracts predicated on cargo-owners'cooperation, which remains doubtful. No effective arrangements have been made to meet the industry's capital requirements, and doubts are more numerous than assurances in the industry. The crisis that has developed is unprecedented.Common Carriers Industry,Ports&Waterways,Transport and Trade Logistics,Water and Industry,Environmental Economics&Policies

FOXL2 and TERT promoter mutation detection in circulating tumor DNA of adult granulosa cell tumors as biomarker for disease monitoring

OBJECTIVE: Adult granulosa cell tumors (aGCTs) represent a rare, hormonally active subtype of ovarian cancer that has a tendency to relapse late and repeatedly. Current serum hormone markers are inaccurate in reflecting tumor burden in a subset of aGCT patients, indicating the need for a novel biomarker. We investigated the presence of circulating tumor DNA (ctDNA) harboring a FOXL2 or TERT promoter mutation in serial plasma samples of aGCT patients to determine its clinical value for monitoring disease. METHODS: In a national multicenter study, plasma samples (n = 110) were prospectively collected from 21 patients with primary (n = 3) or recurrent (n = 18) aGCT harboring a FOXL2 402C > G and/or TERT (C228T or C250T) promoter mutation. Circulating cell-free DNA was extracted and assessed for ctDNA containing one of either mutations using droplet digital PCR (ddPCR). Fractional abundance of FOXL2 mutant and TERT mutant ctDNA was correlated with clinical parameters. RESULTS: FOXL2 mutant ctDNA was found in plasma of 11 out of 14 patients (78.6%) with aGCT with a confirmed FOXL2 mutation. TERT C228T or TERT C250T mutant ctDNA was detected in plasma of 4 of 10 (40%) and 1 of 2 patients, respectively. Both FOXL2 mutant ctDNA and TERT promoter mutant ctDNA levels correlated with disease progression and treatment response in the majority of patients. CONCLUSIONS: FOXL2 mutant ctDNA was present in the majority of aGCT patients and TERT promoter mutant ctDNA has been identified in a smaller subset of patients. Both FOXL2 and TERT mutant ctDNA detection may have clinical value in disease monitoring

Multi-messenger searches via IceCube’s high-energy neutrinos and gravitational-wave detections of LIGO/Virgo

We summarize initial results for high-energy neutrino counterpart searches coinciding with gravitational-wave events in LIGO/Virgo\u27s GWTC-2 catalog using IceCube\u27s neutrino triggers. We did not find any statistically significant high-energy neutrino counterpart and derived upper limits on the time-integrated neutrino emission on Earth as well as the isotropic equivalent energy emitted in high-energy neutrinos for each event